July 13, 2020

Extracellular Vesicles in Metabolism

Dr Juan Manuel Falcón-Pérez has participated in the great iniciative from ISEV: EVTalks. You can find this interesting talk at https://www.youtube.com/watch?v=YVJn_Fcc-6Q

Read More
June 3, 2020

Extracellular vesicles play an important role in the pathology of malaria vivax

Plasmodium vivax is the most widely distributed human malaria parasite, mostly outside sub-Saharan Africa, and responsible for millions of clinical cases yearly, including severe disease and death. The mechanisms by which P. vivax causes disease are not well understood. Recent evidence suggests that, similar to what has been observed with the more lethal P. falciparum, red blood cells infected […]

Read More
June 3, 2020

Vesicles Shed by Pathological Murine Adipocytes Spread Pathology: Characterization and Functional Role of Insulin Resistant/Hypertrophied Adiposomes

Un posible marcador da obesidade nas vesículas extracelulares Científicos do IDIS de Santiago conclúen que as vesículas liberadas por adipocitos obesos e diabéticos inducen estas patoloxías en adipocitos sans. O redescubrimento das vesículas extracelulares (pequenas estruturas liberadas por todas as células do organismo), debido ao papel tan importante que xogan tanto nos procesos fisiolóxicos normais como en […]

Read More
June 2, 2020

Regulation of MT1-MMP Activity through Its Association with ERMs and tetraspanins

Membrane-bound proteases play a key role in biology by degrading matrix proteins or shedding adhesion receptors. MT1-MMP metalloproteinase is critical during cancer invasion, angiogenesis, and development. MT1-MMP activity is strictly regulated by internalization, recycling, autoprocessing but also through its incorporation into tetraspanin-enriched microdomains (TEMs), into invadopodia, or by its secretion on extracellular vesicles (EVs). We […]

Read More
June 2, 2020

MiR-219a-5p enriched extracellular vesicles induce OPC differentiation and EAE improvement more efficiently than liposomes and polymeric nanoparticles.

Remyelination is a key aspect in multiple sclerosis pathology and a special effort is being made to promote it. However, there is still no available treatment to regenerate myelin and several strategies are being scrutinized. Myelination is naturally performed by oligodendrocytes and microRNAs have been postulated as a promising tool to induce oligodendrocyte precursor cell […]

Read More
June 1, 2020

ISEV and ISCT statement on EVs from MSCs and other cells: considerations for potential therapeutic agents to suppress COVID-19

Two members of Tentacles: Dr Falcón-Pérez and Dr Borrás, have participated in the discussion that lead to the joint statement of ISEV and ISCT on the use of EVs on COVID-19. STATEMENT: The International Society for Cellular and Gene Therapies (ISCT) and the International Society for Extracellular Vesicles (ISEV) recognize the potential of extracellular vesicles […]

Read More
May 29, 2020

Polarized Sorting of Patched Enables Cytoneme-Mediated Hedgehog Reception in the Drosophila Wing Disc

The group of Isabel Guerrero at CBM-SO, has recently described how Hedgehog (Hh) signal molecules, which play a fundamental role in development, adult stem cell maintenance and cancer, can signal at a distance via a graded distribution across Drosophila epithelia that is mediated by filopodia-like structures called cytonemes. Hh reception by Patched (Ptc) happens at […]

Read More
May 27, 2020

The malaria parasite ‘P. vivax’ can remain in the spleen upon expression of certain proteins

The malaria parasite Plasmodium vivax can adhere to human spleen cells through the expression of so-called variant proteins. These are the conclusions of a study led by the Barcelona Institute for Global health (ISGlobal), an institution supported by “la Caixa” and the Germans Trias i Pujol Research Institute (IGTP). The results, published in PNAS, suggest that this could […]

Read More
May 27, 2020

¿Se puede monitorizar la fibrosis renal de forma no invasiva?

Un proyecto del IGTP desarrolla un test rápido, barato y efectivo para monitorizar el grado de fibrosis del riñón trasplantado https://www.lavanguardia.com/ciencia/20200518/481150903605/preguntas-big-vang-fibrosis-renal-trasplante-rinon-biomarcador-no-invasivo-francesc-borras-igtp.html

Read More