November 8, 2022

Exosomes loaded with ultrasmall Pt nanoparticles: a novel low-toxicity alternative to cisplatin

In this study, the group of Pilar Martín-Duque showed that a nanoscale vector based on ultrasmall PtNPs and exosomes exhibits antitumoral properties comparable or higher to those of the FDA approved cisplatin. They demonstrated their anticancer properties both in vitro and in vivo comparing the results obtained with the administration of equivalent amounts of cisplatin, […]

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September 22, 2022

A Rapid, Convergent Approach to the Identification of Exosome Inhibitors in Breast Cancer Models

The group of Dr Vicent describe a rapid, convergent, and cost-efficient strategy to analyze candidate U.S. Food and Drug Administration (FDA)-approved drugs that inhibit exosome release and/or biogenesis using breast cancer cell line models in the hope of repurposing them for the clinical treatment of metastatic tumors based on AlphaScreenTM technology The manuscript is available at […]

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September 2, 2022

N-Glycans in Immortalized Mesenchymal Stromal Cell-Derived Extracellular Vesicles Are Critical for EV–Cell Interaction and Functional Activation of Endothelial Cells

A collaborative work from Dr Borrás´s and Dr Falcón-Perez groups demonstrating the functional relevance of N-Glycans on the surface of EVs. The manuscript is available at

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June 14, 2022

Bioimplants with extra-cellular vesicles from stem cells can improve cardiac function after an acute myocardial heart attack

Researchers from the ICREC Group (Cardiac Insufficiency and Regeneration in cardiovascular diseases) at the Germans Trias i Pujol Research Institute (IGTP) continue to work on therapeutic technologies to repair cardiac tissue after a heart attack in collaboration with the IVECAT group (IGTP). In an article published in Theranostics, they present a study of extracellular vesicles […]

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May 4, 2022

Characterization of plasma circulating small extracellular vesicles in patients with metastatic solid tumors and newly diagnosed brain metastasis

A new piece of work from Dr Peinado´s group in which the medical oncologist Alberto Carretero, co-supervised with Guillermo De Velasco Oria de Rueda and Marta Herguetas characterize in depth circulating EVs from patients with brain metastasis. The manuscript is available at

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May 3, 2022

Tetraspanins interweave EV secretion, endosomal network dynamics and cellular metabolism

As part of a Special Issue on EVs on the European J Cell Biology, Víctor Toribio and María Yáñez-Mó discuss how tetraspanins regulate endosomal dynamics and thus impact on EV secretion and cellular metabolism revieweing intriguing new data on this interesting superfamily of proteins. The manuscript is freely available to the scientific community at

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April 28, 2022

Commonly used methods for extracellular vesicles’ enrichment: Implications in downstream analyses and use

As part of a Special Issue on EVs on the European J Cell Biology, a nice update from Dr Borrás group on EV enrichment techniques that will help in decision making for downstream analyses. The manuscript is freely available to the scientific community at

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April 25, 2022

The Contribution of Extracellular Vesicles From Senescent Endothelial and Vascular Smooth Muscle Cells to Vascular Calcification

A mini-review article from GEIVEX members Dr Consuelo Borrás and Dr Matilde Alique. Vascular calcification is an irreversible pathological process associated with a loss of vascular wall function. This process occurs as a result of aging and age-related diseases, such as cardiovascular and chronic kidney diseases, and leads to comorbidities. During these age-related diseases, the […]

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March 30, 2022

ALK-Fusion Transcripts Can Be Detected in Extracellular Vesicles (EVs) from Nonsmall Cell Lung Cancer Cell Lines and Patient Plasma: Toward EV-Based Noninvasive Testing

A great work from the group of Dr Mariano Provencio and Dr Atocha Romero in collaboration with other TeNTaCLES members Dr Valés-Gómez and Dr Pardo. The manuscript is freely available to the scientific community at

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