July 13, 2020

Extracellular Vesicles in Metabolism

Dr Juan Manuel Falcón-Pérez has participated in the great iniciative from ISEV: EVTalks. You can find this interesting talk at https://www.youtube.com/watch?v=YVJn_Fcc-6Q

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June 22, 2020

How extracellular vesicles can enhance drug delivery

When Lydia Alvarez-Erviti started her postdoctoral studies at the University of Oxford, UK, in 2008, her goal was to develop gene therapies for neurodegenerative diseases. She had identified her target — α-synuclein, a protein that accumulates in the brains of people with Parkinson’s disease — and designed a short interfering RNA (siRNA) to reduce the […]

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June 17, 2020

Microvesicles From Indoxyl Sulfate-Treated Endothelial Cells Induce Vascular Calcification in vitro

Vascular calcification (VC), an unpredictable pathophysiological process and critical event in patients with cardiovascular diseases (CVDs), is the leading cause of morbi-mortality and disability in chronic kidney disease (CKD) patients worldwide. Currently, no diagnostic method is available for identifying patients at risk of VC development; the pathology is detected when the process is irreversible. Extracellular […]

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June 3, 2020

Extracellular vesicles play an important role in the pathology of malaria vivax

Plasmodium vivax is the most widely distributed human malaria parasite, mostly outside sub-Saharan Africa, and responsible for millions of clinical cases yearly, including severe disease and death. The mechanisms by which P. vivax causes disease are not well understood. Recent evidence suggests that, similar to what has been observed with the more lethal P. falciparum, red blood cells infected […]

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June 2, 2020

Regulation of MT1-MMP Activity through Its Association with ERMs and tetraspanins

Membrane-bound proteases play a key role in biology by degrading matrix proteins or shedding adhesion receptors. MT1-MMP metalloproteinase is critical during cancer invasion, angiogenesis, and development. MT1-MMP activity is strictly regulated by internalization, recycling, autoprocessing but also through its incorporation into tetraspanin-enriched microdomains (TEMs), into invadopodia, or by its secretion on extracellular vesicles (EVs). We […]

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June 2, 2020

MiR-219a-5p enriched extracellular vesicles induce OPC differentiation and EAE improvement more efficiently than liposomes and polymeric nanoparticles.

Remyelination is a key aspect in multiple sclerosis pathology and a special effort is being made to promote it. However, there is still no available treatment to regenerate myelin and several strategies are being scrutinized. Myelination is naturally performed by oligodendrocytes and microRNAs have been postulated as a promising tool to induce oligodendrocyte precursor cell […]

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June 1, 2020

ISEV and ISCT statement on EVs from MSCs and other cells: considerations for potential therapeutic agents to suppress COVID-19

Two members of GEIVEX board: Dr Falcón-Pérez and Dr Borrás, have participated in the discussion that lead to the joint statement of ISEV and ISCT on the use of EVs on COVID-19. STATEMENT: The International Society for Cellular and Gene Therapies (ISCT) and the International Society for Extracellular Vesicles (ISEV) recognize the potential of extracellular […]

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May 29, 2020

Polarized Sorting of Patched Enables Cytoneme-Mediated Hedgehog Reception in the Drosophila Wing Disc

The group of Isabel Guerrero at CBM-SO, has recently described how Hedgehog (Hh) signal molecules, which play a fundamental role in development, adult stem cell maintenance and cancer, can signal at a distance via a graded distribution across Drosophila epithelia that is mediated by filopodia-like structures called cytonemes. Hh reception by Patched (Ptc) happens at […]

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May 29, 2020

Vesicles Shed by Pathological Murine Adipocytes Spread Pathology: Characterization and Functional Role of Insulin Resistant/Hypertrophied Adiposomes

Un posible marcador da obesidade nas vesículas extracelulares Científicos do IDIS de Santiago conclúen que as vesículas liberadas por adipocitos obesos e diabéticos inducen estas patoloxías en adipocitos sans. O redescubrimento das vesículas extracelulares (pequenas estruturas liberadas por todas as células do organismo), debido ao papel tan importante que xogan tanto nos procesos fisiolóxicos normais como en […]

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