May 3, 2022

Tetraspanins interweave EV secretion, endosomal network dynamics and cellular metabolism

As part of a Special Issue on EVs on the European J Cell Biology, Víctor Toribio and María Yáñez-Mó discuss how tetraspanins regulate endosomal dynamics and thus impact on EV secretion and cellular metabolism revieweing intriguing new data on this interesting superfamily of proteins. The manuscript is freely available to the scientific community at

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April 28, 2022

Commonly used methods for extracellular vesicles’ enrichment: Implications in downstream analyses and use

As part of a Special Issue on EVs on the European J Cell Biology, a nice update from Dr Borrás group on EV enrichment techniques that will help in decision making for downstream analyses. The manuscript is freely available to the scientific community at

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April 25, 2022

The Contribution of Extracellular Vesicles From Senescent Endothelial and Vascular Smooth Muscle Cells to Vascular Calcification

A mini-review article from GEIVEX members Dr Consuelo Borrás and Dr Matilde Alique. Vascular calcification is an irreversible pathological process associated with a loss of vascular wall function. This process occurs as a result of aging and age-related diseases, such as cardiovascular and chronic kidney diseases, and leads to comorbidities. During these age-related diseases, the […]

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March 30, 2022

ALK-Fusion Transcripts Can Be Detected in Extracellular Vesicles (EVs) from Nonsmall Cell Lung Cancer Cell Lines and Patient Plasma: Toward EV-Based Noninvasive Testing

A great work from the group of Dr Mariano Provencio and Dr Atocha Romero in collaboration with other TeNTaCLES members Dr Valés-Gómez and Dr Pardo. The manuscript is freely available to the scientific community at https://academic.oup.com/clinchem/advance-article/doi/10.1093/clinchem/hvac021/6554744#.YkH0kcWcq1s.whatsapp

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February 11, 2022

A simple immunoassay for extracellular vesicle liquid biopsy in microliters of non‑processed plasma

The latest publication from Dr Valés-Gómez group is now available in Journal of Nanobiotechnology. In this article they describe how to detect oncologic biomarkers in exosomes in just 12 microlitres of patients’ plasma. A high-throughput automatable method which allows the study of large cohorts of patients. The manuscript is freely available to the scientific community […]

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November 27, 2021

Special Issue on the Cell Biology of EVs open for submissions

Dr. María Yáñez-Mó and Dr Pia Siljander are Editing this Special Issue in European Journal of Cell Biology open for submissions until 31st December (flexible deadline 🙂

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November 27, 2021

Melanoma-derived small extracellular vesicles induce lymphangiogenesis and metastasis through an NGFR-dependent mechanism

Dr Héctor Peinado publishes in Nature Cancer the relevance of tumoral EV in metastasis and lymphangiogenesis. Congrats to all authors of this terrific work. All details at: https://rdcu.be/cB2V6 https://www.elespanol.com/ciencia/salud/20211125/golpe-espanol-cancer-bloquean-metastasis-melanoma-laboratorio/629937407_0.html

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September 28, 2021

Isolation and characterization of urine microvesicles from prostate cancer patients: different approaches, different visions

A rigorous study from the group of Jose Antonio López Guerrero at IVO highlighting the importance of standardizing the urine EV isolation methods to guaranty the analytical reproducibility necessary for their implementation in a clinical setting. All details at: https://rdcu.be/cyzzX

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July 12, 2021

Inactivation of EMILIN-1 by Proteolysis and Secretion in Small Extracellular Vesicles Favors Melanoma Progression and Metastasis

Another piece of relevant information on the role of EVs in Melanoma metastasis. From Peinado´s group, of course. Congratulations! More details at: https://www.mdpi.com/1422-0067/22/14/7406

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