December 18, 2020

Proteomic Characterization of urinary EVs from kidney Transplanted patients treated with CNIs

REMAR group led by Dr Francesc Borràs has recently published their study on proteomic profiling of urinary EVs. You read the full article at https://www.mdpi.com/1422-0067/21/20/7569

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December 14, 2020

The influence of secreted factors and extracellular vesicles in ovarian cancer metastasis

An excellent review from Dr Peinado´s group in which they summarize the most recent findings in ovarian cancer metastasis, with special focus on the role of secreted factors and extracellular vesicles in ovarian cancer metastasis https://www.sciencedirect.com/science/article/pii/S1359634919300023

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December 9, 2020

Deciphering Adipose Tissue Extracellular Vesicles Protein Cargo and Its Role in Obesity

An excellent review from Dr Pardo´s group in which they describe the most frequent proteins identified in EVs shed by adipose tissue and its components, including their changes under pathological status, to give the reader a whole picture about the membrane/antigens, and intracellular proteins known so far, in an attempt to elucidate functional roles, and […]

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December 9, 2020

Hitting the Bullseye: Are extracellular vesicles on target?

Dr Yáñez-Mó has participated in a recent Editorial that was launched after the coming after last year´s fruitful discussion in Philadelphia in the ISEV Workshop devoted to “Extracellular Vesicle Targetting to cells and Tissues”. https://onlinelibrary.wiley.com/doi/full/10.1002/jev2.12032

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September 8, 2020

The future of Extracellular Vesicles as Theranostics

The utilization of extracellular vesicles (EVs) in clinical theranostics has rapidly advanced in the past decade. In November 2018, the International Society for Extracellular Vesicles (ISEV) held a workshop on “EVs in Clinical Theranostic”, in which both Dr Marcilla and Dr Falcón-Perez participated. You can read in the recently published report, the interesting conclusions of […]

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August 17, 2020

Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers

Moving forward in the use of EVs as disease biomarkers,  this seminal work published in Cell by the group of Dr Lyden with the contribution of Dr Hector Peinado.  Original article can be found here:  https://www.cell.com/cell/fulltext/S0092-8674(20)30874-6

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June 22, 2020

How extracellular vesicles can enhance drug delivery

When Lydia Alvarez-Erviti started her postdoctoral studies at the University of Oxford, UK, in 2008, her goal was to develop gene therapies for neurodegenerative diseases. She had identified her target — α-synuclein, a protein that accumulates in the brains of people with Parkinson’s disease — and designed a short interfering RNA (siRNA) to reduce the […]

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June 17, 2020

Microvesicles From Indoxyl Sulfate-Treated Endothelial Cells Induce Vascular Calcification in vitro

Vascular calcification (VC), an unpredictable pathophysiological process and critical event in patients with cardiovascular diseases (CVDs), is the leading cause of morbi-mortality and disability in chronic kidney disease (CKD) patients worldwide. Currently, no diagnostic method is available for identifying patients at risk of VC development; the pathology is detected when the process is irreversible. Extracellular […]

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June 3, 2020

Extracellular vesicles play an important role in the pathology of malaria vivax

Plasmodium vivax is the most widely distributed human malaria parasite, mostly outside sub-Saharan Africa, and responsible for millions of clinical cases yearly, including severe disease and death. The mechanisms by which P. vivax causes disease are not well understood. Recent evidence suggests that, similar to what has been observed with the more lethal P. falciparum, red blood cells infected […]

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