As part of a Special Issue on EVs on the European J Cell Biology, Víctor Toribio and María Yáñez-Mó discuss how tetraspanins regulate endosomal dynamics and thus impact on EV secretion and cellular metabolism revieweing intriguing new data on this interesting superfamily of proteins.

The manuscript is freely available to the scientific community at

https://www.sciencedirect.com/science/article/pii/S0171933522000322?via%3Dihub#fig0010