April 16, 2021

Targeting Alzheimer’s disease with multimodal polypeptide-based nanoconjugates

Alzheimer’s disease (AD), the most prevalent form of dementia, remains incurable mainly due to our failings in the search for effective pharmacological strategies. Here, we describe the development of targeted multimodal polypeptide-based nanoconjugates as potential AD treatments. Treatment with polypeptide nanoconjugates bearing propargylamine moieties and bisdemethoxycurcumin or genistein afforded neuroprotection and displayed neurotrophic effects, as […]

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April 5, 2021

IPs meeting about EV-associated nucleic acids. March 4th 2021.

Dr Valés-Gómez chaired the discussion on different aspects of biomarker discovery based on the detection of EV-associated nucleic acids. Both Dr Otaegui, Dr Peinado and Dr Valés-Gómez presented their results focused on circular RNAs, DNA or mRNA detection, respectively. A lively discussion about methodologies used, limitations and results-driven solutions was held and some ideas and […]

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April 5, 2021

TeNTaCLES Journal CLUB.

Lola Fernandez-Messina and Elena Castellano took the lead in organizing the TeNTaCLES Journal Club, which is expected to include all researchers (predoc, postdoc and PIs) of the groups in the network to discuss relevant aspects of EV research. The first Seminar took place on February 22nd and dealt with EVs in cancer and metastasis, with […]

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April 5, 2021

IPs meeting about SPREC preanalytical codes. January 18th 2021.

Dr López-Guerrero summarized the concept of SPREC codes and the data from previous reports analysing the experimental evidence in the literature that supports the effect of preanalytical conditions in which biological samples are obtained in the outcome of EV isolation and characterization. SPREC codes are meant to standardize samples among different laboratories and biobanks. There […]

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March 24, 2021

Biomaterial scaffolds containing extracellular vesicles from stem cells to control and promote heart muscle repair after heart attack

Local administration of porcine immunomodulatory, chemotactic and angiogenic extracellular vesicles using engineered cardiac scaffolds for myocardial infarction A collaboration between the iCREC and the IVECAT-REMAR groups from the Institute Germans Trias i Pujol (IGTP) has brought some new light into the therapeutic potential of MSC derived EVs. Check all the details in the link below. […]

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March 17, 2021

Local administration of MSC-EVs in a myocardial infarction model

Local administration of porcine immunomodulatory, chemotactic and angiogenic extracellular vesicles using engineered cardiac scaffolds for myocardial infarction A collaboration between the iCREC and the IVECAT-REMAR groups from the Institute Germans Trias i Pujol (IGTP) has brought some new light into the therapeutic potential of MSC derived EVs. Check all the details in the link below. […]

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January 22, 2021

DNA-Loaded Extracellular Vesicles in Liquid Biopsy: Tiny Players With Big Potential?

Extracellular vesicles, tiny players with big potential ?, some ideas published by Susana Garcia Silva, Miguel Gallardo and Hector Peinado https://www.frontiersin.org/articles/10.3389/fcell.2020.622579/full?&utm_source=Email_to_authors_&utm_medium=Email&utm_content=T1_11.5e1_author&utm_campaign=Email_publication&field&journalName=Frontiers_in_Cell_and_Developmental_Biology&id=622579%E2%80%AC&fbclid=IwAR3ZlWgLIcdyjrsOEPMDZjQXiCrfBh8wtM0ptCRayh6D4Vm7ivjEtIYbBuc

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