Tentacles

Optimization of extracellular vesicle isolation and their separation from lipoproteins by size exclusion chromatography

Just published in The Journal of Extracellular Biology from the group of Dr Yáñez-Mó, in collaboration with Agarose Bead Technologies (ABT). Authors have studied the agarose parameters that define the resolution in size exclussion chromatography to acieve better isolation of EVs from lipoproteins. Congrats to all authors! The full article is available at https://doi.org/10.1002/jex2.100

Extracellular vesicles from the trematodes Fasciola hepatica and Dicrocoelium dendriticum trigger different responses in human THP-1 macrophages

A great work just published in The Journal of Extracellular Vesicles from the group of Dr Marcilla. Extracellular vesicles (EVs) released by the helminths Dicrocoelium dendriticum and Fasciola hepatica are important modulators of the host immune response, contributing to the establishment of the infection. Monocytes and, in particular, macrophages are major regulators of the inflammatory response and are likely […]

Extracellular vesicles from pristane-treated CD38 deficient mice express and antiinflammatory neutrophil protein signature, which reflects the mild lupus severity elicited in these mice

This is an article published in Frontiers in Immunology, as part of the Research Topic:Extracellular Vesicles in Inflammatory Responses and Inflammation-AssociatedDiseases. Researchers from the Dept of Cellular Biology and Immunology, Institute ofParasitology and Biomedicine Lopez-Neyra (IPBLN), CSIC, Granada, present a studyof extracellular vesicles (EV). They analyze the protein composition, proteinabundance, and functional clustering of EV […]

Standardising the preanalytical reporting of biospecimens to improve reproducibility in extracellular vesicle research – A GEIVEX study

The standardization of clinical studies using extracellular vesicles (EVs) has mainly focused on the procedures employed for their isolation and characterization; however, preanalytical aspects of sample collection, handling and storage also significantly impact the reproducibility of results. We conducted an online survey based on SPREC (Standard PREanalytical Code) among members of GEIVEX (Grupo Español de […]

IPs meeting and Hands-on workshop to close TeNTaCLES activities

Dr Hector peinado has been awarded with the Diz Pintado award in cancer research

GEIVEX Treasurer has been awarded with the XII national prize for cancer research Diz Pintado. https://www.lagacetadesalamanca.es/salamanca/hector-peinado-recibe-el-premio-diz-pintado-y-reclama-mas-financiacion-para-luchar-contra-las-metastasis-JH13140382?s=08 https://www.salamanca24horas.com/local/hector-peinado-investigador-cancer-combinacion-de-terapias-dirigidas-con-inmunoterapia-es-futuro_15067587_102.html Congrats to our treasurer!

A simple immunoassay for EV liquid biopsy in microlitres of non-processed plasma

A new participation at ISEV #EVClub in which Carmen Campos and Mar Valés-Gómez have presented their work on developments for detection of EVs from different biofluids https://jnanobiotechnology.biomedcentral.com/articles/10.1186/s12951-022-01256-5 You can find this interesting video at https://www.youtube.com/watch?v=CzR9OnSjpeg

La Dra Maria Jesús Vicent galardonada con el premio de ciencia de Radio Castellón

ENHORABUENA MARIA JESÚS!!! https://cadenaser.com/comunitat-valenciana/2022/09/19/galardonados-de-la-xix-edicion-premios-radio-castellon-radio-castellon/

A Rapid, Convergent Approach to the Identification of Exosome Inhibitors in Breast Cancer Models

The group of Dr Vicent describe a rapid, convergent, and cost-efficient strategy to analyze candidate U.S. Food and Drug Administration (FDA)-approved drugs that inhibit exosome release and/or biogenesis using breast cancer cell line models in the hope of repurposing them for the clinical treatment of metastatic tumors based on AlphaScreenTM technology The manuscript is available at […]