July 12, 2021

Inactivation of EMILIN-1 by Proteolysis and Secretion in Small Extracellular Vesicles Favors Melanoma Progression and Metastasis

Another piece of relevant information on the role of EVs in Melanoma metastasis. From Peinado´s group, of course. Congratulations! More details at: https://www.mdpi.com/1422-0067/22/14/7406

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July 5, 2021

Using single-vesicle technologies to unravel the heterogeneity of extracellular vesicles

Vesicle heterogeneity is a hot topic, and technology is starting to help us to unravel it. Learn more at this great review from Dr Falcón Perex group! https://www.nature.com/articles/s41596-021-00551-z?WT.mc_id=TWT_NatureProtocols&s=08

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June 29, 2021

Physiological models for in vivo imaging and targeting the lymphatic system: Nanoparticles and extracellular vesicles

A great revision on the different animal models focusing on nanoparticles and EVs from the Peinado´s group published on Advanced Drug Delivery Reviews- Congrats! https://www.sciencedirect.com/science/article/abs/pii/S0169409X21002258?dgcid=author

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June 14, 2021

Hector Peinado recibe una Beca Leonardo de la fBBVA

Enhorabuena a Hector por el apoyo de la FUndación BBVA a su proyecto para el desarrollo de nuevos ensayos de biopsia liquida en melanoma.  Héctor Peinado Selgas, jefe de grupo en el Centro Nacional de Investigaciones Oncológicas (CNIO). “Análisis de la mutación BRAF en exomas circulantes de pacientes de melanoma”. Subárea: Investigación traslacional. https://www.redleonardo.es/noticias/adjudicadas-58-becas-leonardo-a-investigadores-y-creadores-culturales-en-9-areas-de-la-ciencia-y-la-cultura/

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May 31, 2021

Mª Jesús Vicent Docón, recibe el premio Concepción Aleixandre de Picanya a la Mujer Científica Valenciana

La investigadora Mª Jesús Vicent Docón, investigadora en polímeros terapéuticos ha sido premiada en la categoría de Comunitat Valenciana. El Ayuntamiento de Picanya entregó los galardones el viernes 28 de Mayo , coincidiendo con el Día Internacional de Acción por la Salud de las Mujeres. Esta tercera edición de los galardones se ha enfocado a […]

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May 12, 2021

CD9 inhibition reveals a functional connection of extracellular vesicle secretion with mitophagy in melanoma cells

A TeNTaCLES collaboration between Yáñez-Mó and Peinado´s groups. Discover how: Tetraspanins are much more than EV markers Plasma membrane is an important source for EV cargo EV biogenesis impacts on mitochondrial quality control Biomedical potential of tetraspanin-targeted blocking peptides in tumor growth All the details at  http://doi.org/10.1002/jev2.12082

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April 16, 2021

Targeting Alzheimer’s disease with multimodal polypeptide-based nanoconjugates

Alzheimer’s disease (AD), the most prevalent form of dementia, remains incurable mainly due to our failings in the search for effective pharmacological strategies. Here, we describe the development of targeted multimodal polypeptide-based nanoconjugates as potential AD treatments. Treatment with polypeptide nanoconjugates bearing propargylamine moieties and bisdemethoxycurcumin or genistein afforded neuroprotection and displayed neurotrophic effects, as […]

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March 24, 2021

Biomaterial scaffolds containing extracellular vesicles from stem cells to control and promote heart muscle repair after heart attack

Local administration of porcine immunomodulatory, chemotactic and angiogenic extracellular vesicles using engineered cardiac scaffolds for myocardial infarction A collaboration between the iCREC and the IVECAT-REMAR groups from the Institute Germans Trias i Pujol (IGTP) has brought some new light into the therapeutic potential of MSC derived EVs. Check all the details in the link below. […]

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