The group of Dr Pardo have have published a ground-breaking study of EVs on Obesity and its comorbidities. They isolated and characterized extracellular vesicles (EVs) shed by whole human obese visceral (VAT) and subcutaneous (SAT) adipose tissues to perform the first proteome reference map and comparative analysis. Further validation shows that obese AT release EVs carrying adipose and obesity candidate biomarkers. Moreover, their findings suggest that circulating EV-TFGBI may facilitate monitoring T2D status in obese patients, and EV-mimecan may be useful to track adiposity