The utilization of extracellular vesicles (EVs) in clinical theranostics has rapidly advanced in the past decade. In November 2018, the International Society for Extracellular Vesicles (ISEV) held a workshop on “EVs in Clinical Theranostic”, in which both Dr Marcilla and Dr Falcón-Perez participated. You can read in the recently published report, the interesting conclusions of […]
Read MoreMoving forward in the use of EVs as disease biomarkers, this seminal work published in Cell by the group of Dr Lyden with the contribution of Dr Hector Peinado. Original article can be found here: https://www.cell.com/cell/fulltext/S0092-8674(20)30874-6
Read MoreDr Juan Manuel Falcón-Pérez has participated in the great iniciative from ISEV: EVTalks. You can find this interesting talk at https://www.youtube.com/watch?v=YVJn_Fcc-6Q
Read MoreWhen Lydia Alvarez-Erviti started her postdoctoral studies at the University of Oxford, UK, in 2008, her goal was to develop gene therapies for neurodegenerative diseases. She had identified her target — α-synuclein, a protein that accumulates in the brains of people with Parkinson’s disease — and designed a short interfering RNA (siRNA) to reduce the […]
Read MoreVascular calcification (VC), an unpredictable pathophysiological process and critical event in patients with cardiovascular diseases (CVDs), is the leading cause of morbi-mortality and disability in chronic kidney disease (CKD) patients worldwide. Currently, no diagnostic method is available for identifying patients at risk of VC development; the pathology is detected when the process is irreversible. Extracellular […]
Read MorePlasmodium vivax is the most widely distributed human malaria parasite, mostly outside sub-Saharan Africa, and responsible for millions of clinical cases yearly, including severe disease and death. The mechanisms by which P. vivax causes disease are not well understood. Recent evidence suggests that, similar to what has been observed with the more lethal P. falciparum, red blood cells infected […]
Read MoreMembrane-bound proteases play a key role in biology by degrading matrix proteins or shedding adhesion receptors. MT1-MMP metalloproteinase is critical during cancer invasion, angiogenesis, and development. MT1-MMP activity is strictly regulated by internalization, recycling, autoprocessing but also through its incorporation into tetraspanin-enriched microdomains (TEMs), into invadopodia, or by its secretion on extracellular vesicles (EVs). We […]
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